Physical Education
Asra Askari; Amir Rashidlamir; Nahid Bijeh; Majid momeni-moghaddam
Volume 25, Issue 3 , July and August 2018, , Pages 451-460
Abstract
Background:Neurotrophin-3 is among the biomarkers studied in MS.Regarding the fact that Exercise training has been proposed as an effective non-drug way of treating Multiple Sclerosis(MS),the present study aims at investigatingthe effect of eight weeks’ aquatic exercise and resistance training ...
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Background:Neurotrophin-3 is among the biomarkers studied in MS.Regarding the fact that Exercise training has been proposed as an effective non-drug way of treating Multiple Sclerosis(MS),the present study aims at investigatingthe effect of eight weeks’ aquatic exercise and resistance training programs on the plasmatic levels and gene expression of neurotrophin-3in MS patients.Materials and methods:To the aims of the present study,30women with MS were randomly selected and assigned to three groups:the control group,resistance training group,and aquatic exercise group. Resistance training and aquatic exercise programs were used for 8weeks.After separating plasma and PBMNcells,plasmatic levels and the expression of neurotrophin-3gene were measured via ELISA and real-timePCR,respectively.Inorder to compare the means,plasmatic levels and the gene expression of neurotrophin-3of the three groups were Analyzed by the ANCOVAtest at the significance level of p≤0.05through SPSS18. Results:The results showed a significant increase in plasma levels neurotrophin-3of the three groups (p=0.001).The Scheffe post hoc test was significant in two by two comparisons of the aquatic group and resistance training group with the control group (p=0.001,p=0.001,respectively).However,the difference between the aquatic and resistance groups was not significant(p=0.329).Moreover,there was a significant increase in the gene expression of neurotrophin-3of the three groups(p=0.001).Based on the Scheffe test,the mean differences between the aquatic and resistance groups,and the control group were(p=0.053,p=0.001,respectively).However,non-significant differences in the gene expression of neurotrophin-3were shown between the aquatic group and the resistance group(p=0.08).Conclusion:The findings of the present study indicated that both the resistance training and the aquatic exercise can increase plasmatic levels and the gene expression of neurotrophin-3in MS patients.